We never really saw Shizune Fight though Remember that. We saw her use needles once I think, and that was about it. Though Remember Kakashi is Easily Above Jounin Level, He's probably at Sannin Levels, and he was killed by I think it was 2 peins. Then you also have to consider Konohamaru basically destroyed one, somehow. Which means he has to be stronger than even shizune. Which is odd, but I look forward to seeing him more no doubt. Shizune's Mind was taken by PEin I think. So she may have a small sliver of a chance to come back, however what's the point of killing people in the manga only to bring them back, He pretty much exhausted that with Gaara.
Thats mainly why I think Kakashi is Dead, and Shizune is. Not Sure about Konohamaru but he's probably alive, due to the fact he killed one pein, and I doubt he'd be killed easily by a shockwave. Though Personally I think Gai is the next to die, Gai, Lee, and Yamato, are probably the only ones who can save naruto. Gai because of his ability to open all the gates, Lee is there because of his ability to open the gates, and Yamato ACtually has the sealing ability.
Though I cant think Gai would die there, mainly cause he is probably the one to kill Kisame, or the other guy is, Forgot his name. Also gai is probably one of the closer jounins to Kakashi, and viewed him as a rival and friend. So he might as well finish what kakashi couldnt. It is personally my firm believe that Gai is stronger than Kakashi, and Tsunade, do to those gates, and it would only make sense for the manga to show all 8 gates, since they at the beginning stated the power would be far greater than that of even a Hokage. So they have to use them.
Now since I'm basically labeling what happens since Kakashi died. With Sasuke and Naruto, Kakashi was the bond that held them together. Either in Kakashi's Death, That bond falls apart, and Finally We get the Battle Sasuke vs Naruto that will be held to the end, with Naruto Killing Sasuke. Or Sasuke and Naruto Come together to Destroy Akatsuki. However the prior is more likely to happen.